Discussion of diabetes management in day to day life





Prandin and weight gain?

My doctor has me taking 1mg of Prandin 15 to 30 minutes before lunch and
dinner. This has been going on for approx. 1 1/2 months. In that time
I’ve gained 12 pounds even though my diet is basically the same as it
was before I started using Prandin. Prandin is the ONLY change.

I know that Prandin causes my beta cells to dump more insulin into my
bloodstream. Is that increase causing my weight gain?

Me: T2 taking 12u Humolog with each meal 3× per day, 66u Lantus
between 9:00 and 10:00pm, 1mg Prandin with lunch and dinner.

posted by admin in Uncategorized and have Comments (7)






7 Responses to “Prandin and weight gain?”

  1. admin says:

    My endocrinologist makes a big point that insulin and drugs that cause the
    body to produce more insulin cause weight gain. She also warned me intensely
    that Actos/Avandia have caused weight gain in most of her patients and that
    she doesn’t like to prescribe them for that reason.

    Since you are already injecting insulin, it seems odd to be taking a drug
    that pushes your cells to make more insulin. Why not just inject a bit more?

    My HMO won’t pay for Prandin or Starlix except at the very highest co-pay
    level, which they say is because they aren’t happy with its effects on
    patients. They will pay for quite a few other new drugs at lower co-pay
    levels.

    – Jenny  - Low Carbing for 5 years. Below goal for weight. Type 2 diabetes,
    hba1c 5.7 .
    Cut the carbs to respond to my  email address!

    Jenny’s new site: What they Don’t Tell You About Diabetes
    http://www.geocities.com/lottadata4u/

    Jenny’s Low Carb Diet Facts & Figures
    http://www.geocities.com/jenny_the_bean/

    Looking for help controlling your blood sugar?
    Visit  http://www.alt-support-diabetes.org/Newly%20Diagnosed.htm

    "daveosaurus" <dsau…@webtv.net> wrote in message

    news:253-412FBE31-29@storefull-3217.bay.webtv.net…
    My doctor has me taking 1mg of Prandin 15 to 30 minutes before lunch and
    dinner. This has been going on for approx. 1 1/2 months. In that time
    I’ve gained 12 pounds even though my diet is basically the same as it
    was before I started using Prandin. Prandin is the ONLY change.

    I know that Prandin causes my beta cells to dump more insulin into my
    bloodstream. Is that increase causing my weight gain?

    Me: T2 taking 12u Humolog with each meal 3× per day, 66u Lantus
    between 9:00 and 10:00pm, 1mg Prandin with lunch and dinner.

  2. admin says:

    daveosaurus wrote in message

    <253-412FBE31…@storefull-3217.bay.webtv.net>…
    My doctor has me taking 1mg of Prandin 15 to 30 minutes before lunch and
    dinner. This has been going on for approx. 1 1/2 months. In that time
    I’ve gained 12 pounds even though my diet is basically the same as it
    was before I started using Prandin. Prandin is the ONLY change.

    I know that Prandin causes my beta cells to dump more insulin into my
    bloodstream. Is that increase causing my weight gain?

    Me: T2 taking 12u Humolog with each meal 3× per day, 66u Lantus
    between 9:00 and 10:00pm, 1mg Prandin with lunch and dinner.

    You are taking two power-insulins  (Humalog and Lantus) in a reasonable,
    modern basal-bolus regime.    You ought to have excellent control with no
    need for Prandin,  i.e. adjust your Humalog to control your after meal
    sugars;  adjust your Lantus to control your fasting blood sugar.

     Many docs regard insulin injections as a "replacement" for beta stimulator
    such as Prandin not a supplement.

    You are shooting quite a bit of insulin.  That and the fact that you didn’t
    mention an anti-Insulin Resistance med makes me think you aren’t taking one.

    Anti-Insulin Resistance meds are considered anti-diabetic heart attack meds,
    and premature heart attack is considered the #1 problem for Type 2 diabetes.
    You might ask your doc about metformin which is about the most popular
    anti-Insulin Resistance med in use.

    Some light reading

    Metformin cuts blood sugars and heart attack risk in T2

    http://www.diabetesnet.com/diabetes_treatments/metformin.php

    Regards
      Old Al

  3. admin says:

    The description of "wet macular degeneration" sounds identical to me to that
    given for diabetic retinopathy–growth of blood vessels in the retina which
    leak and cause blindness.

    Are these really the same entity or is there some significant difference
    I’ve missed?
     – Jenny  - Low Carbing for 5 years. Below goal for weight. Type 2
    diabetes, hba1c 5.7 .
    Cut the carbs to respond to my  email address!

    Jenny’s new site: What they Don’t Tell You About Diabetes
    http://www.geocities.com/lottadata4u/

    Jenny’s Low Carb Diet Facts & Figures
    http://www.geocities.com/jenny_the_bean/

    Looking for help controlling your blood sugar?
    Visit  http://www.alt-support-diabetes.org/Newly%20Diagnosed.htm

    "oldal4865" <oldal4…@yahoo.com> wrote in message

    news:2pa3sjFiv213U1@uni-berlin.de…

    - Hide quoted text — Show quoted text -

    > daveosaurus wrote in message
    > <253-412FBE31…@storefull-3217.bay.webtv.net>…
    > My doctor has me taking 1mg of Prandin 15 to 30 minutes before lunch and
    > dinner. This has been going on for approx. 1 1/2 months. In that time
    > I’ve gained 12 pounds even though my diet is basically the same as it
    > was before I started using Prandin. Prandin is the ONLY change.

    > I know that Prandin causes my beta cells to dump more insulin into my
    > bloodstream. Is that increase causing my weight gain?

    > Me: T2 taking 12u Humolog with each meal 3× per day, 66u Lantus
    > between 9:00 and 10:00pm, 1mg Prandin with lunch and dinner.

    > You are taking two power-insulins  (Humalog and Lantus) in a reasonable,
    > modern basal-bolus regime.    You ought to have excellent control with no
    > need for Prandin,  i.e. adjust your Humalog to control your after meal
    > sugars;  adjust your Lantus to control your fasting blood sugar.

    >  Many docs regard insulin injections as a "replacement" for beta
    stimulator
    > such as Prandin not a supplement.

    > You are shooting quite a bit of insulin.  That and the fact that you
    didn’t
    > mention an anti-Insulin Resistance med makes me think you aren’t taking
    one.

    > Anti-Insulin Resistance meds are considered anti-diabetic heart attack
    meds,
    > and premature heart attack is considered the #1 problem for Type 2
    diabetes.
    > You might ask your doc about metformin which is about the most popular
    > anti-Insulin Resistance med in use.

    > Some light reading

    > Metformin cuts blood sugars and heart attack risk in T2

    > http://www.diabetesnet.com/diabetes_treatments/metformin.php

    > Regards
    >   Old Al

  4. admin says:

    "daveosaurus" <dsau…@webtv.net> wrote in message

    news:253-412FBE31-29@storefull-3217.bay.webtv.net…
    I know that Prandin causes my beta cells to dump more insulin into my
    bloodstream. Is that increase causing my weight gain?

    Probably. I was started on Prandin (0.5mg), and I did get a weight peak the
    first couple of weeks, but this didn’t prevent weight loss to start the
    following weeks. It just felt weird, because I was barely eating these first
    few weeks (stress from learning my diabetic state had a dramatic effect on
    my appetite), yet the weight was creeping on.
    I must say I’m glad to be off that drug now (and any drug for that matter).
    After a while, I was getting constant reactive hypoglycemia after my meals,
    something I never had before. Besides, I have always eaten small breakfast
    without problems, but Prandin was incompatible with that and forced me to
    eat a large breakfast without being hungry or face feeling like shit from
    hypoglycemia the whole morning. Hypoglycemia also got in the way of
    exercising, and the answer of my doc to that was not very satisfactory
    ("stop exercising").
    Though I must admit it was pretty easy on the side effects; except for the
    hypoglycemia I didn’t get any. Just be warned that the drug is pretty
    sensitive to how long you take it before the meal. The worst memory was
    taking the drug before going to a restaurant (most of my friends don’t know
    I’m diabetic, I don’t like publicizing the fact) and drinking a glass of
    alcohol, and then waiting for ages to get my meal while both the drug and
    alcohol where driving me into hypoglycemia. :p Even taking the drug 5 or 30
    minutes before the meal instead of 15 minutes could make a lot of difference
    (I guess depending on whether it leaves the stomach before the food
    arrives).
    It does feel weird that you inject on top of Prandin though. :-o

  5. admin says:

    "Jenny" <lottadataca…@hotmail.com> wrote in message <news:41308873$0$19722$61fed72c@news.rcn.com>…
    > The description of "wet macular degeneration" sounds identical to me to that
    > given for diabetic retinopathy–growth of blood vessels in the retina which
    > leak and cause blindness.

    > Are these really the same entity or is there some significant difference
    > I’ve missed?

    I’ve wondered the same thing.  Of course, I didn’t think to ask my eye
    doctor.

    My father supposedly had macular degeneration from smoking and not
    protecting his eyes from the sun.  My mom supposedly has it from 2nd
    hand smoke and not protecting her eyes from the sun (hers improved
    after she lost some weight and started eating a better diet).  I
    suspect that, in my mom’s case, she might have a bg problem she’s
    hiding from me (she’s almost 87 and very secretive).

    pc

  6. admin says:

    On 29 Aug 2004 20:59:09 -0700, poodlebre…@netscape.net (pinecone)
    wrote:

    - Hide quoted text — Show quoted text -

    >"Jenny" <lottadataca…@hotmail.com> wrote in message <news:41308873$0$19722$61fed72c@news.rcn.com>…
    >> The description of "wet macular degeneration" sounds identical to me to that
    >> given for diabetic retinopathy–growth of blood vessels in the retina which
    >> leak and cause blindness.

    >> Are these really the same entity or is there some significant difference
    >> I’ve missed?

    >I’ve wondered the same thing.  Of course, I didn’t think to ask my eye
    >doctor.

    >My father supposedly had macular degeneration from smoking and not
    >protecting his eyes from the sun.  My mom supposedly has it from 2nd
    >hand smoke and not protecting her eyes from the sun (hers improved
    >after she lost some weight and started eating a better diet).  I
    >suspect that, in my mom’s case, she might have a bg problem she’s
    >hiding from me (she’s almost 87 and very secretive).

    >pc

    I am one that requires frequent laser burns to seal leaking blood
    vessels. in the retina area. This a diabetes problem.
    The link will give a lot of info. on the more general problem.

    http://www.mayoclinic.com/invoke.cfm?id=DS00284

                                                     Guy

  7. admin says:

    On Sat, 28 Aug 2004 09:25:19 -0400, "Jenny"

    <lottadataca…@hotmail.com> wrote:
    >The description of "wet macular degeneration" sounds identical to me to that
    >given for diabetic retinopathy–growth of blood vessels in the retina which
    >leak and cause blindness.

    >Are these really the same entity or is there some significant difference
    >I’ve missed?
    > — Jenny  - Low Carbing for 5 years. Below goal for weight. Type 2
    >diabetes, hba1c 5.7 .
    >Cut the carbs to respond to my  email address!

    the macula is the very small portion of the eye that allows you to
    read, and see detail.  the retina is much larger than the macula.
    damage to one can be independent of the other.

    Mâck©®
    Type 1 since 1975
    http://www.alt-support-diabetes.org
    http://www.diabetic-talk.org
    http://www.insulin-pumpers.org

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