Magnes Res. 2004 Jun;17(2):109-14. Related Articles, Links
Long term magnesium supplementation influences favourably the
natural evolution of neuropathy in Mg-depleted type 1 diabetic patients
(T1dm).
De Leeuw I, Engelen W, De Block C, Van Gaal L.
Department Diabetology, Metabolism and Clinical nutrition,
University Hospital Antwerp, Belgium. ivo.dele…@ua.ac.be
Chronic Mg depletion in T1dm has been linked to polyneuropathy (PNP).
Short term Mg supplementation has suggested a decrease in pathological
EMG signs typical for PNP. The aim of this study is to determine if long
term supplementation under stable metabolic control can normalize the Mg
status and influence the natural evolution of PNP. 110 T1dm with chronic
Mg depletion (erythrocyte Mg < 2.3 mMol/l) were randomised to receive
300 mg Mg++ daily or no supplement for a period of 5 years. Follow-up
was organized by the same diabetologist: HbA1c, renal function and Mg
status every 3 months, electromyography (EMG) and clinical neurological
control with staging every year. Drop-out was decided for recurrent DKA,
diseases or drugs interfering with Mg status or side-effects of Mg
treatment. 97 patients finished the study: 49 were supplemented (group
A) and 48 served as controls (group B). At the start there were no
significant differences between both groups. HbA1c after 5 years
(A:7.80%, B:7.75%) was not significantly different from the start.
Erythrocyte Mg (Mg rbc) rose significantly in group A to normal levels
but remained low in group B. Staging of PNP after 5 years shows a
decrease in 39%, statu quo in 49% and a worsening in 12% in group A and
8, 31 and 61% respectively in group B. Normalization of EMG signs was
only seen in incipient PNP. Logistic regression analysis shows that
longer duration of diabetes (p < 0.006) and low Mgrbc (p < 0.05) are the
major determinants of PNP evolution. Under stable metabolic control long
term Mg supplementation is able to restore a normal Mg status and
influence favourably the natural evolution of PNP as compared to non
supplemented T1dm controls.
PMID: 15319143 [PubMed - in process]
Frank
"Jefferson" <croom1…@netscape.net> wrote in message
news:KMCdnWRyo8MoAz_cRVn-og@adelphia.com…
> Magnes Res. 2004 Jun;17(2):109-14. Related Articles, Links
> Long term magnesium supplementation influences favourably the natural
> evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm).
How do you know whether you’re deficient in magnesium?
Nicky.
–
HbA1c 10.5/6.4/<6 Weight 95/79/72
1g Metformin, 75ug Thyroxine
T2 DX 05/2004
Nicky wrote:
> "Jefferson" <croom1…@netscape.net> wrote in message
> news:KMCdnWRyo8MoAz_cRVn-og@adelphia.com…
>> Magnes Res. 2004 Jun;17(2):109-14. Related Articles, Links
>> Long term magnesium supplementation influences favourably the natural
>>evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm).
> How do you know whether you’re deficient in magnesium?
The erythocyte is a red blood cell corpuscle. Presumably, a blood test
could be used to determine the magnesium content. T1dm with chronic Mg
depletion (erythrocyte Mg less than 2.3 mMol/l).
"RESEARCH DESIGN AND METHODS—In the Women’s Health Study, a cohort of
39,345 U.S. women aged >=45 years with no previous history of
cardiovascular disease, cancer, or type 2 diabetes completed validated
semiquantitative food frequency questionnaires in 1993 and were followed
for an average of 6 years.
Magnesium is a cofactor in several enzymes critical for carbohydrate
metabolism (1) and is believed to play a role in glucose homeostasis,
insulin action, and the development of type 2 diabetes (1,2).
Hypomagnesemia has been shown to occur frequently among patients with
diabetes, especially those with poor metabolic control (2). Several
cross-sectional studies have also observed an inverse association
between plasma or erythrocyte magnesium levels and fasting insulin
levels in diabetic patients and apparently healthy individuals (3,4).
Accumulating evidence also suggests an inverse association between serum
or plasma magnesium levels and risk of type 2 diabetes, indicating a
potential role of magnesium status in the pathogenesis of type 2
diabetes (3,5,6)." Source: Dietary Magnesium Intake in Relation to
Plasma Insulin Levels and Risk of Type 2 Diabetes in Women –
http://care.diabetesjournals.org/cgi/content/full/27/1/59
There is more in this article, but this excerpt is enough information
to get you started.
Frank
In article <30hgo1F31c2p…@uni-berlin.de>,
Nicky <ukc802466…@btconnect.com> wrote:
>"Jefferson" <croom1…@netscape.net> wrote in message
>news:KMCdnWRyo8MoAz_cRVn-og@adelphia.com…
>> Magnes Res. 2004 Jun;17(2):109-14. Related Articles, Links
>> Long term magnesium supplementation influences favourably the natural
>> evolution of neuropathy in Mg-depleted type 1 diabetic patients (T1dm).
>How do you know whether you’re deficient in magnesium?
Your blood level of magnesium should be determined at any
routine physical. However, I do not know how relevant
this is for magnesium; it is not for some minerals, and
extremely good for others.
—
This address is for information only. I do not claim that these views
are those of the Statistics Department or of Purdue University.
Herman Rubin, Department of Statistics, Purdue University
hru…@stat.purdue.edu Phone: (765)494-6054 FAX: (765)494-0558
IMHO, if Mg depletion is suspected, a blood test will be taken.
However, even if the blood level appears normal, if symptoms of
depletion appear which are improved by supplementation, then a diagnosis
of Mg depletion could also be made.
Per the Merck Manual, "Hypomagnesemia [low level of Mg in the blood] is
often present when Mg depletion is severe.". In other words, if
magnesium is depleted, the blood levels of magnesium will probably be
abnormally low. However, it is possible that it may not. From the same
source: "Severe hypomagnesemia often is equated with Mg depletion.
However, plasma Mg concentration, even if free Mg ion is measured, may
not reflect the status of intracellular or bone Mg stores.".
From my reading, it appears that Mg depletion is usually a byproduct of
other problems like chronic diarrhea or alcoholism.
Possible symptoms: "On the basis of experimental Mg depletion in human
volunteers, the clinical manifestations of Mg deficiency are anorexia,
nausea, vomiting, lethargy, weakness, personality change, tetany (eg,
positive Trousseau’s or Chvostek’s sign or spontaneous carpopedal
spasm), and tremor and muscle fasciculations."
"Herman Rubin" <hru…@odds.stat.purdue.edu> wrote in message
news:co2hki$b2m@odds.stat.purdue.edu…
- Hide quoted text — Show quoted text -
> In article <30hgo1F31c2p…@uni-berlin.de>,
> Nicky <ukc802466…@btconnect.com> wrote:
> >"Jefferson" <croom1…@netscape.net> wrote in message
> >news:KMCdnWRyo8MoAz_cRVn-og@adelphia.com…
> >> Magnes Res. 2004 Jun;17(2):109-14. Related Articles, Links
> >> Long term magnesium supplementation influences favourably the
natural
> >> evolution of neuropathy in Mg-depleted type 1 diabetic patients
(T1dm).
> >How do you know whether you’re deficient in magnesium?
> Your blood level of magnesium should be determined at any
> routine physical. However, I do not know how relevant
> this is for magnesium; it is not for some minerals, and
> extremely good for others.
> —
> This address is for information only. I do not claim that these views
> are those of the Statistics Department or of Purdue University.
> Herman Rubin, Department of Statistics, Purdue University
> hru…@stat.purdue.edu Phone: (765)494-6054 FAX:
(765)494-0558
"Ludwig" <lud…@dontemailme.com> wrote in message
news:zgTpd.62$sc5.21@fe61.usenetserver.com…
> Possible symptoms: "On the basis of experimental Mg depletion in human
> volunteers, the clinical manifestations of Mg deficiency are anorexia,
> nausea, vomiting, lethargy, weakness, personality change, tetany (eg,
> positive Trousseau’s or Chvostek’s sign or spontaneous carpopedal
> spasm), and tremor and muscle fasciculations."
>> Nicky <ukc802466…@btconnect.com> wrote:
>> >How do you know whether you’re deficient in magnesium?
Thanks, Ludwig.
Nicky.