Acta Biochim Pol. 2004;51(2):471-80. Related Articles, Links
The role of labile iron pool in cardiovascular diseases.
Kruszewski M.
Department of Radiobiology and Health Protection, Institute of Nuclear
Chemistry and Technology, Warszawa, Poland.
Although multiple factors are associated with cardiovascular pathology, there
is now an impressive body of evidence that free radicals and nonradical
oxidants might cause a number of cardiovascular dysfunctions. Both direct
damage to cellular components and/or oxidation of extracellular biomolecules,
e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The
key molecules in this process seem to be iron and copper ions that catalyse
formation of the highly reactive hydroxyl radical. Chelation of iron ions has a
beneficial effect on the processes associated with the development of
atherosclerosis and formation of post-ischemic lesions. These findings are
indirectly supported by the increasing body of evidence that stored body iron
plays a crucial role in pathogenesis of atherosclerosis and
ischemia/reperfusion injury.
PMID: 15218543 [PubMed - in process]
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