I am flying for the first time since diagnosis. Is there any problem
carrying the glucometer and lancing device in my carry on? Or do they
have to be in the checked luggage?

"This is the first time that a protein like this has ever been found"

Hmmmm ..

Anybody use these drugs .. ?

http://www.peacehealth.org/kbase/topic/detail/drug/hw133689/detail.htm

Thiazolidinediones for type 2 diabetes
Examples
Generic Name Brand Name
pioglitazone Actos
rosiglitazone Avandia
rosiglitazone and metformin Avandamet

Metformin is a biguanide medication. For more information, see the
Medications section of the topic Type 2 Diabetes: Recently Diagnosed.

The thiazolidinedione medication troglitazone (Rezulin) has been
removed from the market in the United States and some European
countries. Troglitazone has been shown to cause severe liver problems
in a small number of people who take it.

How It Works
The action of these medications in treating type 2 diabetes is not
completely understood. They improve the way cells in the body respond
to insulin by lowering insulin resistance. Unlike some other
medications used to treat diabetes, they do not cause the pancreas to
produce more insulin.

——————————————————————————————————————

<<snip>>
the thiazolidinediones may protect cells from the damaging effects of
free iron by keeping the iron-sulfur cluster attached to mitoNEET.
<<snip>>

Source: University of California – San Diego
Date: September 6, 2007

Discovery May Pave The Way For A New Class Of Diabetes Drugs
Science Daily – A multidisciplinary team led by researchers at the
University of California, San Diego has determined the structure of a
protein found in cells that shows potential as a target for the
development of new drugs to treat diabetes.

The study, published September 4 in the journal Proceedings of the
National Academy of Sciences, described the structure of a protein-
MitoNEET-that was previously identified as a site where diabetes drugs
could operate.  The discovery of the protein’s three-dimensional
structure makes it possible to design small molecules that interact
with it and modify its function.  The researchers say that MitoNEET
has a novel three-dimensional structure that makes it a particularly
interesting candidate for the design of innovative compounds that can
bind to it.

"This is the first time that a protein like this has ever been found,"
said Patricia Jennings, a professor in UCSD’s department of Chemistry
and Biochemistry who led the study along with Mark Paddock, a project
scientist in UCSD’s Physics department.  "It is a brand new structure,
a unique beast, which makes it an exciting target for structure-based
drug design. We are grateful about the highly collaborative spirit of
the UCSD community that brought such diverse expertise and helped us
tackle such a complex project."

"Our work may provide a basis for the design of newer diabetes drugs
that have potentially greater specificity and fewer side effects than
existing ones," added Paddock.

Following the initial work of co-authors Sandra Wiley, Anne Murphy and
Jack Dixon at UCSD’s School of Medicine, and in collaboration with
Herbert Axelrod and Aina Cohen at the Stanford Synchrotron Radiation
Laboratory and Rachel Nechushtai at the Hebrew University of
Jerusalem, also co-authors on the paper, the team determined that
mitoNEET is an iron-sulfur protein. Iron-sulfur proteins have a
variety of functions, including electron transfer, which is critical
to cell metabolism, and the storage and transport of iron.  In its
free state, iron is highly toxic to cells and can lead to oxidative
stress-the accumulation of reactive compounds that can damage the
cell.

MitoNEET’s iron-sulfur cluster is loosely bound, a property that may
be linked to one of its functions.  When mitoNEET binds the type 2
diabetes drug Actos®, the iron-sulfur cluster becomes more stable.
This drug was thought to work through an entirely different mechanism
involving a different protein.  However, the finding by Jerry Colca,
presently at Metabolic Solutions Development Company in Kalamazoo,
Michigan, that the thiazolidinediones-the class of diabetes drugs of
which Actos®  is a member-bind to mitoNEET indicated a possible
mechanism involving mitoNEET.  Colca’s finding inspired the UCSD-led
study, which suggests that Actos® and similar drugs may protect cells
from the damaging effects of free iron by keeping the iron-sulfur
cluster attached to mitoNEET.

>From mitoNEET’s structure, location and properties, it could also play

a role as a sensor of oxidative stress in the cell.  Oxidative stress
is a problem in many diseases including diabetes.  MitoNEET is
confined to the mitochondria-structures within cells that convert
nutrients into energy-where reactive compounds accumulate as nutrients
are metabolized.  MitoNEET’s structure would allow it to transfer
electrons to and from, and therefore detect, these compounds.

"MitoNEET may be an example of an ever increasing group of proteins
found to have more than one function. I think we are at the beginning
of what is sure to be an interesting and biologically important
puzzle." said Paddock.

"It is intriguing to see these different pieces coming together,"
explained Jennings.  "There is growing evidence that mitochondrial
dysfunction and compromised oxidative capacity is a problem in
diabetes.  MitoNEET has iron-sulfur clusters that can transfer
electrons, and it binds insulin-sensitizing drugs.  Now that we know
the structure and physical properties of the protein we can use this
knowledge for drug studies and studies of biological function."

The team plans to use the new structural information for designing
more sophisticated experiments to test function and structure-based
drug design to create drugs that interact better with mitoNEET.
Collaborative experiments are currently underway with Colca’s group at
Metabolic Solutions Development Company.

"This work is a great example of the possible synergies of a
multidisciplinary and multinational effort," said Paddock.
"Instrumental in these results were the combined efforts of the US and
Israeli teams."

Other UCSD co-authors of the paper were Edward Abresch in Physics and
Melinda Roy and Dominique Capraro in Chemistry and Biochemistry.

The study was supported by the National Institutes of Health, the
Department of Energy and the Zevi Hermann Shapira Foundation.

Note: This story has been adapted from a news release issued by
University of California – San Diego.

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Fat builds up in heart before diabetes onset:

http://www.healthday.com/Article.asp?AID=607815

Hi All,
I just reopened www.thriftysams.com with more then a million products it
has the latest feeds concerning all health product needs.
Respectfully,
Fran G
www.type1diabetic.com

Just published in several different sources:

http://care.diabetesjournals.org/misc/dc9925consensus.pdf

Consensus Statement on the Worldwide Standardization of the
Hemoglobin A1C Measurement

The American Diabetes Association, European Association for
the Study of Diabetes, International Federation of Clinical
Chemistry and Laboratory Medicine, and the International
Diabetes Federation

My selective snippets follow – read the full text for more
detail:
<snip>
The hemoglobin A1C (A1C) assay has become the gold-standard
measurement of chronic glycemia for over two decades.
<snip>
The clinical world has assumed that the A1C assay reflects
average glycemia over the preceding few months. However,
the data supporting that premise are not exceptionally
robust (1–5); glucose concentrations were not measured
frequently enough to compute a true “average.” To gain a
better understanding of the relationship between A1C and
average blood glucose, an international study has been
initiated to document this relationship, using frequent
capillary measurements and continuous glucose monitoring.

The results of this study will be known around September
2007.
<snip>
However, to achieve a more uniform standardization
of A1C measurements, it is desirable to have a reference
method that measures only a well-defined analyte.
<snip>
In keeping with the measurement of other analytes, the IFCC
has also suggested that the test results be provided in
scientifically correct units, i.e., mmol/mol (13). The
impact of both changes proposed by the IFCC would be to
significantly change the numeric results provided
to clinicians. For example, an A1C value of 5% would become
~33 mmol/ mol and an 8% would be ~65 mmol/mol.

Cheers, Alan, T2, Australia.
d&e, metformin 1500mg, ezetrol 10mg
Everything in Moderation – Except Laughter.
—
http://loraldiabetes.blogspot.com

convicted friend Kathy Claytor (KC) wrote:

- — -

> "Ozgirl" wrote:
> > "Kurt" <kurtwheeling1…@hotmail.com>  wrote:

> >> http://tinyurl.com/ywtk9j

> >> (excerpt)

> >> NEW YORK – A new, large study suggests that treating women who develop
> >> diabetes during pregnancy greatly reduces the chances that their baby
> >> will become obese during childhood.

> >> The research found that the higher the mother’s blood sugar levels,
> >> the greater the child’s risk of being obese by age 5 to 7, even if the
> >> mother wasn’t diagnosed with diabetes.

> >> Untreated high blood sugar nearly doubled the child’s risk of becoming
> >> overweight or obese, said the study’s lead author, Dr. Teresa Hillier
> >> of Kaiser Permanente’s Center for Health Research in Portland, Ore.

> >> That higher risk disappeared, however, when women with diabetes
> >> followed a special diet, exercised or were given insulin. Their
> >> children had about the same risk of becoming obese as those whose
> >> mothers had normal blood sugar, the researchers found.

> > I have no one else to compare to but my 5 GD kids are skinny rails. One
> > was a little chubby but not obese, right before onset of puberty.  I was
> > also treated aggressively.

> I always worry about my kids getting obese.  I had pre-existing diabetes
> during my 3 pregnancies.  My first daughter got to be a real chub between
> the ages of 4 months to 4 years, but thankfully got thin after that.  My
> other 2 have been normal weight so far.  I don’t think any of mine are
> really thin as rails though.  Time will tell, but I am thankful that the
> scientists are working on obesity treatments so much, so that hopefully my
> kids will have it better than I.

Things are unlikely to get better for you until you become convinced
in your heart that hunger is wonderful.

May reading the following help you:

http://abchung.livejournal.com/5428.html?thread=36660#t36660

Prayerfully in Jesus’ awesome love,

Andrew <><
—
Andrew B. Chung, MD/PhD
Cardiologist

on Premierleague Bundesliga Serie A
Uefa Cup

www.scommessadelgiorno.blogspot.com

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go now

–
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Pronostici
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Dritte
Scommesse
News

http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.107.7…

Be hungry… be healthy… be hungrier… be blessed:

http://TheWellnessFoundation.com/PressRelease

Prayerfully in Jesus’ awesome love,

Andrew <><
—
Andrew B. Chung, MD/PhD
Cardiologist

- — -

Julie Bove wrote:
> Just got my latest labs back.

> Last year was:

> Cholesterol: 171
> LDL: 101
> HDL: 36
> Triglycerides: 168

> Now:

> Cholesterol   113
> LDL:  40
> HDL:  44
> Triglycerides:  144

> So apparently the statin did do some good although the HDL is still not in
> range.  That’s supposed to be >44.

Optimally, HDL should be greater than 50 mg/dl.

This does happen when folks lose the VAT getting their WHR less than
0.75 (0.85 for men).

Truly, it is only when we are hungry that our bodies get rid of the
VAT.

Hunger is wonderful

Be hungry… be healthy… be hungrier… be blessed:

http://TheWellnessFoundation.com/PressRelease

Prayerfully in Jesus’ awesome love,

Andrew <><
—
Andrew B. Chung, MD/PhD
Cardiologist

It won’t make any diff I reckon, but I made a leap today. I discovered how
to block a sender and more importantly, to remove ALL messages sent by said
sender.

In the first instance it’s Mr MI5 himself and it was truly wonderful to see
all his posts disappear in an instant.

Today, I is mostly happy and tomorrow it could be Chump who goes in the bin.

–
Beav

VN 750
Zed 1000
OMF# 19