Fructose Sweetener Spurs Obesity
Jul 29 2005

FRIDAY, July 29 (HealthDay News) — Another study finds that high
consumption of soft drinks and other sweetened beverages contributes to
obesity. But this study, conducted in mice, suggests that one form of
natural sweetener — fructose — may be especially likely to encourage
weight gain.

In the study, researchers at the University of Cincinnati allowed mice to
freely consume either plain water or fructose-sweetened water and soft
drinks.

The mice that drank the fructose-sweetened water and soft drinks gained
weight, even though they took in fewer calories from solid food.

By the end of the study, the mice that consumed fructose-sweetened
beverages had 90 percent more body fat than the mice that consumed water
only.

The findings suggest that the total amount of calories consumed when
someone includes fructose in their diets may not be the only cause of
weight gain. Consuming fructose may actually affect metabolism in a way
that leads to more fat storage, at least in mice, the researchers said.

"Our study shows how fat mass increases as a direct consequence of soft
drink consumption," study author Dr. Matthias Tschop, associate professor
in the University of Cincinnati’s psychiatry department and a member of the
Obesity Research Center at the university’s Genome Research Institute, said
in a prepared statement.

"We were surprised to see that mice actually ate less when exposed to
fructose-sweetened beverages, and therefore didn’t consume more overall
calories. Nevertheless, they gained significantly more body fat within a
few weeks," Tschop said.

The study appears in the July issue of the journal Obesity Research.

Normally, when I inject Lantus, I inject it into my hip.  I achieved
very good control with my regimen.
However, I decided to inject it into my abdomen for a time last week.
I made sure to do it in the opposite side of my belly as my Novolog, to
ensure they didn’t mix.  When I did that, I lost my great control, and
routinely had readings over 200, while eating the exact same stuff and
injecting the same amount of NovoLog.
I decided to go back to the hip for my Lantus.
My control returned.

This goes to show, that at least for me, location can indeed have a
profound impact on an insulin’s effectiveness.

normaly my BG does not fall below 105 -110 unless I’ve just finished working
out. However when it does fall below 105 I get SOOOOOO hungry that I break
out in sweats and my stomach hurts.  Today I was putting together a jogging
stroller and had to stop to get something to eat b/c I was sweating and felt
like throwing up.  I tested and my BG was 104….5 hours after eating. I’m
wondering if my body "thinks" that I am going hypo at 100ish instead of the
normal 60-70 range for regular people??  Is there any solution for this?

http://groups.yahoo.com/group/aspartameNM/message/1190
study links aspartame to cancer, CBSNews.com, Daniel J Denoon,
Michael W Smith MD: Martin R Weihrauch, MD 2004 Oct,  skeptical review, full
plain text; California OEHHA aspartame critique 2004.03.12: Murray
2005.07.30

[ Comments by Rich Murray are in square brackets.

Rich Murray, MA  Room For All  rmfor...@comcast.net  505-501-2298
1943 Otowi Road    Santa Fe, New Mexico 87505   USA
http://groups.yahoo.com/group/aspartameNM/messages
group with 186 members, 1,191 posts in a public, searchable archive ]

http://annonc.oxfordjournals.org/cgi/content/full/15/10/1460 free full text

Ann Oncol. 2004 Oct; 15(10): 1460-5.
Artificial sweeteners– do they bear a carcinogenic risk?
Weihrauch MR, Diehl V.
Department of Internal Medicine I of the University of Cologne, Cologne,
Germany. martin.weihra…@uni-koeln.de; v.di…@uni-koeln.de;

Abstract

Artificial sweeteners are added to a wide variety of food, drinks, drugs and
hygiene products.
Since their introduction, the mass media have reported about potential
cancer risks,
which has contributed to undermine the public’s sense of security.
It can be assumed that every citizen of Western countries uses artificial
sweeteners, knowingly or not.
A cancer-inducing activity of one of these substances would mean a health
risk to an entire population.
We performed several PubMed searches of the National Library of
Medicine for articles in English about artificial sweeteners.
These articles included ‘first generation’ sweeteners such as saccharin,
cyclamate and aspartame, as well as ‘new generation’ sweeteners such as
acesulfame-K, sucralose, alitame and neotame.
Epidemiological studies in humans did not find the bladder cancer-inducing
effects of saccharin and cyclamate that had been reported from animal
studies in rats.
Despite some rather unscientific assumptions,
there is no evidence that aspartame is carcinogenic.
Case-control studies showed an elevated relative risk of 1.3 for heavy
artificial sweetener use (no specific substances specified) of >1.7 g/day.
For new generation sweeteners, it is too early to establish any
epidemiological evidence about possible carcinogenic risks.
As many artificial sweeteners are combined in today’s products,
the carcinogenic risk of a single substance is difficult to assess.
However, according to the current literature,
the possible risk of artificial sweeteners to induce cancer seems to be
negligible.
Publication Types: Review  PMID: 15367404
Key words: aspartame, cancer, cyclamate, saccharin, sweeteners

Annals of Oncology 2004 15(10): 1460-1465; doi:10.1093/annonc/mdh256
© 2004 European Society for Medical Oncology

Artificial sweeteners-do they bear a carcinogenic risk?
M. R. Weihrauch* and V. Diehl
Department of Internal Medicine I of the University of Cologne, Cologne,
Germany
* Correspondence to: Dr M. R. Weihrauch, Immunologisches Labor Haus 16,
Uniklinik Koeln, Joseph-Stelzmann-Strasse 9, 50924 Koeln, Germany.
Tel. +49-221-4784488; Fax: +49-221-4785912;
martin.weihra…@uni-koeln.de;  v.di…@uni-koeln.de;

"Aspartame entered the market in 1981 as the third artificial sweetener,
and was free of any suspicions regarding carcinogenicity."

[ In fact, at that time,the FDAs own expert Board of Inquiry voted against
approval of aspartame, due to unresolved concerns about its carcinogenicity,
and was arbitrarily overruled by the brand new Commissioner, Arthur Hull
Hayes, appointed by the new President Reagan:

http://www.dorway.com/upipart1.txt
http://groups.yahoo.com/group/aspartameNM/message/262
aspartame expose 96K Oct 1987 Part 1/3: Gregory Gordon, UPI reporter:
Murray 2000.07.10 rmforall

http://www.dorway.com/enclosur.html
http://groups.yahoo.com/group/aspartameNM/message/53
aspartame history Part 1/4 1964-1976: Gold: Murray 1999.11.06  rmforall

http://groups.yahoo.com/group/aspartameNM/message/927
Donald Rumsfeld, 1977 head of Searle Corp., got aspartame FDA approval:
Turner: Murray 2002.12.23 rmforall ]

Claim: "Animal studies showed that aspartame does not have any
cancer-inducing effects, even in very high doses [28, 29]."

[ Sources of funding are not given, nor are any possible linkages to vested
interests listed.

Both reviews are five pages long.
Is the 2004 review (in English) substantially different from the 2001 review
(in German)?
The most recent reference in the 2004 study is in 2001,
but refers to a January 1973 aspartame industry study,
which was not published in a peer-reviewed mainstream scientific journal:

32. Study E33-34 in Master file 134 on aspartame.
On file at the FDA Hearing Clerk's Office 2001.

At the end of this post I give the full text of the 3-page California OEHHA
aspartame critique 2004.03.12: Carcinogenicity Data Summary: Aspartame,
which is critical of the flawed aspartame industry study  E33-34 (Searle
Laboratories, 1973), which stated:

"There is, however, some carcinogenicity concern over observations of brain
tumors in aspartame-treated rats.

Reliable animal studies have not been conducted despite the widespread human
exposure to this artificial sweetener.

Epidemiologic data provide inadequate information on which to judge
carcinogenicity....

Further epidemiologic and toxicologic studies are needed on the
carcinogenicity of this chemical.

No large epidemiological studies of carcinogenicity have been conducted."

Obviously, Weihrauch and Diehl are less than candid in their reference to
this biased study, and this in turn indicates their probable bias.

Remarkably, Weihrauch and Diehl do not mention stevia at all, although it
has been a dominant sweetener in Japan for decades,
while its safety is supported by 25 studies in the last twelve years:

http://groups.yahoo.com/group/aspartameNM/message/1179
Stevia (stevioside) is safe: Prof. Jan M.C. Geuns: Murray 2005.07.06

http://groups.yahoo.com/group/aspartameNM/message/1122
UN FAO & WHO approve Steviol glycosides as sweetener June 2004, imports to
UK no longer blocked: Martini: Murray 2004.10.17 rmforall

http://groups.yahoo.com/group/aspartameNM/message/1084
26 stevia safety abstracts since 1993: aspartame vs stevia debate on
alt.support.diabetes, George Schmidt, OD: Murray 2004.05.25 rmforall

http://groups.yahoo.com/group/aspartameNM/message/1164
artificial sweetener sales soar, stevia and tagatose available: Murray
2005.03.31 rmforall

http://groups.yahoo.com/group/aspartameNM/message/1152
reply to Ferne Hudson, Tate & Lyle PLC, re Splenda (sucralose) policy:
Murray 2005.02.08 rmforall

Claim: "DNA repair assays for the evaluation of genotoxicity of substances
did not show any DNA-damaging properties for aspartame, cyclamate,
saccharin, acesulfame-K or sucralose [30]. "

Note the striking experimental evidence to the contrary for all of these
sweeteners, except acesulfame-K and stevia, reported by Yu F Sasaki’s expert
team in Japan in 2002 August, summarized below, near the end of this post.

It is significant that they did not discuss or reference the seminal
experimental study by C Trocho and M Alameny in 1998 June that demonstrated
that aspartame at the low dose of 10 mg/kg for 10 days causes formaldehyde
adducts to DNA, RNA, and proteins in the cells of rats:

http://groups.yahoo.com/group/aspartameNM/message/925
aspartame puts formaldehyde adducts into tissues, Part 1/2
full text, Trocho & Alemany 1998.06.26: Murray 2002.12.22 rmforall

So far, no aspartame toxicity studies, epidemological or experimental, have
controlled for other major simultaneous, ubiquitous sources of methanol and
formaldehyde in humans.  However, the expert review of methanol
(formaldehyde, formic acid) toxicity by M Bouchard et al in 2001 makes it
clear that very little has been established about the nature and toxicity of
the substantial durable, cululative products of methanol in human tissues:

http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition: Bouchard M et al, full
plain text, 2001: substantial sources are degradation of fruit pectins,
liquors, aspartame, smoke: Murray 2005.04.02 rmforall

Arch Environ Health 2001 Jul-Aug; 56(4): 300-11.
Embryo toxicity and teratogenicity of formaldehyde. [100 references]
Thrasher JD, Kilburn KH.  toxicol…@drthrasher.org
Sam-1 Trust, Alto, New Mexico, USA.
http://www.drthrasher.org/formaldehyde_embryo_toxicity.html   full text

Thrasher (2001): "The major difference is that the Japanese demonstrated
the incorporation of FA and its metabolites into the placenta and fetus.
The quantity of radioactivity remaining in maternal and fetal tissues
at 48 hours was 26.9% of the administered dose." [ Ref. 14-16 ]

http://groups.yahoo.com/group/aspartameNM/message/939
aspartame (aspartic acid, phenylalanine) binding to DNA:
Karikas July 1998: Murray 2003.01.05 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
Dept. of Chemistry, University of Athens, Greece
http://www.chem.uoa.gr   gkoko…@atlas.uoa.gr
"K.H. Schulpis" <inchi…@otenet.gr>  "G.J. Reclos" rek…@otenet.gr  ]
****************************************************************

[ Daniel J. DeNoon in this and another article this year on aspartame
research gives candid, detailed,  and balanced reportage that is unusual in
mainstream public media in the USA on this vital subject, in which adroit
vested interest PR campaigns have for decades orchestrated a prejudicial
climate, inimical to actual presentation and open discussion of the complex
strands of evidence. ]

http://www.cbsnews.com/stories/2005/07/28/health/webmd/main712605.shtml

Study Links Aspartame To Cancer   July 28, 2005    (CBS)

By Daniel J. DeNoon
Reviewed by Michael W. Smith, MD
© 2005, WebMD Inc. All rights reserved.

"We cannot continue to use aspartame in 6,000 types of products, soft
drinks, yogurt, and whatever."  Morando Soffritti, MD

*Are Artificial
…

read more »

I know the number to be under after meals is 140, but tonight, I had a
late night snack of some strawberries and whipped cream. (It had been 3
or 4 hours since dinner.) I tested before and was at 98. An hour later
I was 130, and another hour later I was at 105. At first I thought all
was okay, but then I wondered if a jump of 32 points was a bad thing,
especially for just about a cup and a half of food.

Pete
T2

Does Medicare have an allowance for diabetic shoes under the plan?

When I workout (lift weights) and test my BG after it is usually very low
(for me). Lower than even my fasting BG.  Now if I understand T2 correctly
either I’m not making enough Insulin or my cells don;t recognize the insulin
optimaly. But after working out there is some mechanism that makes cells
hyper-sensitive to the insulin.  Is there any research being done into this
mechanism????

spon…@cox.net wrote:
> Anyone going to be taking Byetta??? (www.byetta.com ) The
new
> injectable T2 med for those NOT in good control???

> If so, I’ve started a new Byetta Support Group so we can
‘share’ this
> experience at:

Is it moderated and if so are people allowed to discuss carb
control as part of controlling their type 2 diabetes? In my
opinion if you don’t make an attempt to change your diet,
excercise level etc then no amount of drugs will give you
good control.

www.nejm.org
cholesterol drugs may harm ill diabetics

A houston TY Station  internet site has an article
on new information that is interesting.   I
could not establish a direct link to it.

So go to this page and follow your nose.

 http://www.click2houston.com/health/index.html

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